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The IGF-1 Trade-Off: Performance vs. Longevity

FoundMyFitness · explainer · Watch on YouTube

Fitness, sleep & longevityMedicine & infectious disease

What it is

A short FoundMyFitness explainer on the trade-off between growth hormone/IGF-1 and longevity. Higher IGF-1 helps muscle and cognition, while lower levels are linked to longer lifespan and stress resistance.

Why Hacker News recommends it

Linked in discussions of diet, aging and cancer as a quick summary of how IGF-1 and mTOR growth signaling cut against longevity.

  • 1 people recommended it
  • 1 different months
  • 0 strong recommendations
  • first 2014, last 2022

What HN commenters said

  1. “video is replete with examples of the effects of low IGF-1/GH or high IGF-1/GH both in animal models and humans.”

    Effects of low versus high IGF-1 in animals and humans

    dpatrick86, 2014-10 · Recommendation · in “What will it take to run a 2-hour marathon?”

Excerpts from Hacker News comments, linked to the originals. Summaries and labels were written by a language model from those comments.

Topics: igf-1, growth hormone, aging, caloric restriction, mtor

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